TRERF1 and hypertriglyceridemia: The elevation of TG lipids has also been found in Rapa treated hypertriglyceridemia patients as well as the tsc2 mutated mouse embryonic fibroblast (MEF) cells, which indicated that mTOR suppressed TG accumulation, can also occur in some other cells and patients [26,64,65] We also attempted to incorporate triple labeled stable isotope labeling by amino acids in cell culture (SILAC) proteomics to correlate any identifiable metabolic or lipidomic enzymes to our isotope tracing results (see Supplemental Materials Section, Figures S15 and S16) for multi-omics analyses.