Ko and colleagues identified that the 189 amino acid isoform of VEGF (VEGF189), but not other VEGF isoforms, is preferentially enriched in small EVs that are secreted by ovarian, colorectal, and renal cancer cells and are present in body fluids of patients with these cancers, and that VEGF189 is bound to the surface of these EVs [53]. This evidence concerns the gene VEGFA and renal carcinoma.