By evaluating the amounts of VEGF189 in small EVs secreted by cancer cells that express VEGF189, and assaying the binding of ‘free’ recombinant VEGF189 to small EVs secreted by VEGF-deficient cancer cells, the authors estimated that post-secretion binding accounts for only ~25% of the VEGF189 in small EVs, implicating that de novo synthesized VEGF189 is largely sorted to small EVs [53]. Here, VEGFA is linked to cancer.