As summarized in Table S1 (Model 1), PON-arylesterase activity was a significant predictor associated with T2D development, since an increase in one unit of its activity caused a decrease in the odds of being diagnosed with T2D (Odds Ratio, O.R., (95% Confidence Interval, 95%CI): 0.97 (0.96–0.98)). Here, PON1 is linked to type 2 diabetes mellitus.