As displayed in Figure 2, both men and women with PON-arylesterase levels lower than the highest quartile had greater odds of being affected by T2D (Women: O.R. (95% Confidence Interval): 2.74 (1.62–4.62); Men: 1.76 (1.11–2.78)). This evidence concerns the gene PON1 and type 2 diabetes mellitus.