Involvement of the neural isoform of tTG, i.e., tTG6 was suggested in the pathogenesis of several neurodegenerative disorders including Alzheimer’s Disease (AD) and Huntington’s Disease (HD), where tTG6 was reported to contribute to the resolution of abnormally accumulated amyloid and microtubule-associated proteins [10]. The gene discussed is TGM2; the disease is Huntington disease.