Several studies show that supplementation with probiotics ameliorates skin inflammation in psoriasis model mice: Lactobacillus pentosus GMNL-77 administration reduced skin scores in IMQ-induced psoriasiform dermatitis and decreased the expression of TNF-α, IL-6, IL-23, IL-17A, IL-17F, and IL-22 in the skin lesions and decreased the numbers of Th17 and Th22 cells in the spleen [102]. The gene discussed is TNF; the disease is psoriasis.