Oral administration of genistein in psoriasis patients for 8 weeks impaired the transcription of genes overexpressed in psoriasis, CXCL10, IL-6, STAT3, NFKB1, CCL4 while stimulated the transcription of gene repressed in psoriasis, IL-1RN in peripheral blood cells or lesional skin [75]. This evidence concerns the gene STAT3 and psoriasis.