Obesity is a chronic low level inflammatory state, and visceral fat-derived adipokines like TNF-α, leptin or visfatin induce the production of psoriasis-promoting antimicrobial peptides, human β-defensin-2/3 or chemokines, CXCL8/10, CCL20 in epidermal keratinocytes, and link metabolic syndromes to psoriasis [5,6,7]. The gene discussed is CXCL8; the disease is psoriasis.