In 2014, researchers at Array Biopharma Inc. developed and patented different 5-pyrazolyl-ureas able to inhibit TrkA and claimed it as useful for the treatment of pain, cancer, inflammation, Sjogren’s syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, neurodegenerative and infectious diseases, and others. This evidence concerns the gene NTRK1 and cancer.