In 2014, researchers at Array Biopharma Inc. developed and patented different 5-pyrazolyl-ureas able to inhibit TrkA and claimed it as useful for the treatment of pain, cancer, inflammation, Sjogren’s syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, neurodegenerative and infectious diseases, and others. The gene discussed is NTRK1; the disease is urogenital neoplasm.