The synthesis of new JNK inhibitors has been pursued to develop efficacious therapeutics for Parkinson’s disease (PD) and other neurodegenerative diseases, such as Alzheimer’s disease (AD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), but also for treatment of myocardial infarction (MI), metabolic disorders, cancer, and inflammatory diseases [33,34]. The gene discussed is MAPK8; the disease is Parkinson disease.