We observed a statistically significant association with OS of colorectal cancer patients for four MMP2 tagging SNPs (rs17301608, rs2241145, rs1561217 and rs243847), all located in introns or in non-coding exon regions, while a previous association of the MMP2 rs243865 (−1306 C > T-in our study the linked SNP rs243866 was genotyped, r2: 0.99) in smaller studies of OS or CRC risk was not confirmed [26,27]. The gene discussed is MMP2; the disease is colorectal cancer.