SNPs in MMP2, EFNB2 and JAG1, which were significantly associated with patients’ survival, were subsequently analyzed in a first validation set of 2165 (for MMP2 and JAG1), and 1638 (for EFNB2) DACHS colorectal cancer patients and a second validations set of 372 colorectal cancer patients from TCGA where genome-wide data was available. The gene discussed is MMP2; the disease is colorectal cancer.