Some indication for interaction was observed for two tagging SNPs in ETS1 (rs11221322 and rs7121854: pinteraction: 0.0004 and 0.001, respectively) and the candidate missense variant in TEK V486I (pinteraction: 0.003) with MSI (microsatellite instability), for the candidate missense variant KDR Q472H (rs1870377; pinteraction: 0.03) with smoking, for the candidate missense variant TEK V486I (rs1334811, pinteraction: 0.03) with NSAID use and for the IL10 candidate rs1800890 (pinteraction: 0.01) with adjuvant 5-FU-based chemotherapy for overall survival of colorectal cancer patients. This evidence concerns the gene TEK and colorectal cancer.