NECTIN4 and neoplasm: However, patients with strong Nectin-4 expression in tumors had a significantly higher risk of tumor progression (Log-rank test, p = 0.031; Figure 4C) or cancer-specific mortality (Log-rank test, p = 0.036; Figure 4D) than patients who did not show strong Nectin-4 expression in tumors (0/1+/2+ vs. 3+).