In patients with moderate-to-severe CKD (stages 2–5), obesity worsens secondary hyperparathyroidism and, regardless of CKD, obesity is associated with hyperparathyroidism [218], increased PTH levels, insulin resistance, and low-grade inflammation but not with WAT browning [217,218,219,220]. The gene discussed is PTH; the disease is obesity due to melanocortin 4 receptor deficiency.