It has been shown that Fn modulates several immune responses towards CRC tumor progression, influencing the pre-tumoral environment [39], inducing the production of inflammatory mediators (IL-6, IL-8, IL-1β) [40], transforming growth factor (TGF)-β and TNF-α [41], and suppressing antitumor immunity by the secretion of Fap2, a natural killer inhibitory ligand [42]. Here, TNF is linked to neoplasm.