Similarly, ApcMin/+ mice (carrying a mutation predisposing them to intestinal adenoma and tumor formation) transplanted with feces from CRC patients showed an increase in the number of intestinal tumors, downregulated expression of mucin-2, regenerating islet-derived protein and intestinal secretory immunoglobulin A, upregulation of the NLRP3 inflammasome, and increased production of pro-inflammatory cytokines IL-1β and tumor necrosis factor (TNF)-α. This evidence concerns the gene TNF and colorectal carcinoma.