PRDX2 and cancer: Unlike PRDX1 knockout, a knockout of the PRDX2 gene does not promote an increase of cancer incidence in animals, but it contributes to the development of hemolytic anemia, due to an important role in the antioxidant defense of erythrocytes, where Prx2 is the third abundant protein after hemoglobin and carbonic anhydrase [35,36].