In human melanoma A375 cells, miR-21 promotes proliferation, migration, and suppresses apoptosis by inhibiting Sprouty 1 (SPRY1), programmed cell death 4 (PDCD4), PTEN and cyclin-dependent kinase inhibitor 2C (CDKN2C) [32,39,40]. Here, CDKN2C is linked to melanoma.