In accordance, co-delivery of 5-fluorouracil (5-FU) and miR-21 inhibitor oligonucleotide (miR-21i) with engineered exosomes to colorectal cancer cells (HCT-1165FR) significantly down-regulated miR-21, induced cell cycle arrest, reduced tumor proliferation, increased apoptosis and rescued PTEN and hMSH2 expressions, regulatory targets of miR-21 [372]. Here, PTEN is linked to neoplasm.