Immunohistochemical analysis of primary non-small cell lung cancer (NSCLC) samples, comparing tumours with associated bone metastases, to tumours with visceral metastases and non-metastatic tumours for expression of bone sialoprotein (BSP) demonstrated a significant correlation between BSP expression and the development of bone metastases (p < 0.001) as well as worse disease outcomes (p < 0.02) [127]. The gene discussed is IBSP; the disease is non-small cell lung carcinoma.