In addition, mutations were detected within all patients sequenced for hepatocyte nuclear factor 1 alpha (HNF1α), adenomatous polyposis coli (APC), and CD22 with an over 50% mutation frequency (being 75%, 62.5%, and 50%, respectively) suggesting that these may be the genes with the greatest potential to account for bone metastasis within lung cancer patients [38]. This evidence concerns the gene APC and lung carcinoma.