DIO3 and Familial prostate cancer: Genetic studies have identified a cluster of micro-RNAs located on chromosome 14q32 implicated in prostate cancer bone metastasis, including the delta-like-1 homolog—deiodinase, iodothyronine 3 (DLK1-DIO3) region encompassing miR-154* (an additional micro-RNA from the miR-154 hairpin), miR-379 and miR-409-3p/-5p, all upregulated within prostate cancer and correlated with cancer spread to bone [88,89,90].