The modulation of immune cell activity within the tumor stroma applies to the various T cell subsets, e.g., CD8+ T cells and CD4+ TH1 T cells predominantly exhibit anti-cancer effects whereby their strong infiltration and accumulation in various solid tumor tissues such as breast, ovarian, cervical, lung and colorectal cancers induces tumor reduction with a favorable patient prognosis. This evidence concerns the gene CD4 and cancer.