DYRK1A and cancer: Of all the DYRKs, only DYRK1A has been identified in high-throughput cancer studies, initially as a potential tumor suppressor using Tumor Suppressor and Oncogene Explorer (TUSON), a method developed to predict the potential of a given gene to act as a tumor suppressor, or oncogene, by computing somatic mutation profiles and copy number alterations (CNAs) [41].