DYRK1A and central nervous system cancer: Additionally, the ß-carboline alkaloid harmine selectively inhibits DYRK1A and—albeit, less efficiently—other members of the family [178,179], and it has been reported to have cytotoxic effects on cancer cell lines [66,85,180,181] and antitumor effects in vivo in glioma and in PDAC xenograft experiments [66,68], as well as synergistic effects with other chemotherapeutic agents [79,80,182].