For DYRK2, experimental data on the antitumor effects of the natural DYRK2 inhibitor curcumin and of the synthetic compound LDN192960 was obtained in both in vitro and in vivo models of TNBC and multiple myeloma, supporting the hypothesis that DYRK2 is a promising pharmaceutical target in these malignancies [134,162]. This evidence concerns the gene DYRK2 and AL amyloidosis.