DYRK2 and breast cancer: As such, DYRK2 protein levels were shown to inversely correlate with tumor invasiveness [56], and enhanced 10-year disease-free survival was evident in DYRK2-positive breast cancer patients when compared to DYRK2-negative patients [147], while a stronger DYRK2 mRNA expression was associated with a worse prognosis in another study of breast cancer patients [148].