DYRK1A and neoplasm: In the following sections, we will discuss the evidence indicating that each member of the DYRK family is involved in cancer by considering two main aspects: (i) alterations to the DYRK expression in tumor tissues, either based on published reports or on our own analysis of The Cancer Genome Atlas (TCGA: see Table S1; only cancer type cohorts with at least 10 paired samples, matched tumor-healthy tissue, were considered in the analysis), and (ii) the impact of DYRK-dependent phosphorylation on substrates involved in cancer-related events.