After profiling the methylation in SMA patients and healthy controls, Zheleznyakova et al. identified differential degrees of methylation at CpG sites in the following genes; CHM Like Rab Escort Protein (CHML), Rho GTPase Activating Protein 22 (ARHGAP22), Cytokinesis And Spindle Organization B (CYTSB), Cyclin Dependent Kinase 2 Associated Protein 1 (CDK2AP1), and Solute Carrier Family 23 Member 2 (SLC23A2) [94]. Here, ARHGAP22 is linked to proximal spinal muscular atrophy.