TP53 and medullary thyroid gland carcinoma: The most common driver genetic alterations observed in DTC include mutations in murine sarcoma viral oncogene homolog B (BRAF), rat sarcoma (RAS), and RET (rearranged-during-transfection)/PTC rearrangements; in PDTC and ATC, TP53 (tumor protein p53) mutations are often observed; and in MTC, point mutations in RET oncogene and pathogenic RAS variants are common.