The other genetic alterations to be predominantly observed in less differentiated thyroid cancer include mutations in the members of the DNA Mismatch Repair pathway (MSH2—MutS Homolog 2, MSH6—MutS Homolog 6, and MLH1—MutL Homolog 1); members of the SWI-SNF chromatin remodeling complex; eukaryotic translation initiation factor 1A (EIF1AX); histone methyl-transferases (HMTs); and isocitrate dehydrogenase 1 (IDH1) [7] (Figure 2 and Table 1). This evidence concerns the gene MSH2 and thyroid cancer.