Mutations in the PIK3CA oncogene and in the CTNNB1 gene that encodes for β-catenin are known to occur in BE and changes in several tumor suppressor genes involved in chromatin remodeling, such as ARID1A and SMARCA4 as well as in TP53 and SMAD4 are usually found in tissues with high-grade dysplasia and EAC. This evidence concerns the gene TP53 and neoplasm.