Most of the clinicopathological factors, including age, T or N stage, tumor grade, expression of HR or HER2, CTx, brain metastasis, and liver metastasis significantly affected OS, though type of breast surgery (mastectomy vs. BCS, p = 0.861) and the presence of bone metastasis (p = 0.984) did not. The gene discussed is ERBB2; the disease is bone metastasis.