In addition to c-MET mutations, other genetic abnormalities are commonly observed in HPRCCs: trisomies of chromosomes 7 and 17 are common in HPRCCs [24]; trisomy 7 harboring non-random duplication of the mutant c-MET proto-oncogene seems to play a significant role in the development of multiple renal tumors [25,26]; multifocal bilateral renal tumors of hereditary PRCC develop as different clones in the renal parenchyma [25]. This evidence concerns the gene MET and kidney neoplasm.