Furuya et al. recently reported the clinicopathologial and molecular features of 13 Japanese patients with hereditary FH-deficient renal cell carcinomas: most tumors had type 2 papillary architecture or tubulocystic pattern or both; at immunohistochemical level, 10 tumors were positive for PD-L1; somatic mutation analysis showed loss of heterozygosity of FH in 10 tumors [70]. This evidence concerns the gene CD274 and renal cell carcinoma.