The miR-1 and miR-206 regulate their target genes of the PPP (pentose phosphate pathway) (Glucose-6-phosphate dehydrogenase (G6PD), Phosphogluconate Dehydrogenase (PGD), Transketolase (TKT), and Transaldolase 1 (TALDO1)) [88], suggesting that suppression of these miRNAs expression caused by NRF2 aberrant activation may enhance tumor development through glucose metabolism deficiency. This evidence concerns the gene NFE2L2 and neoplasm.