In HepG2 cells, a significant decrease in cell proliferation and upregulation of proapoptotic genes BAX and Caspase 3 were observed when PRDX1 was silenced, suggesting the prosurvival and tumorigenic roles of PRDX1. Furthermore, proteomic analysis has revealed changes in expression and oxidation of proteins involved in central metabolism and tumor growth, indicating that PRDX1 is one of metabolic reprogramming factors in cancer cells [86]. This evidence concerns the gene PRDX1 and neoplasm.