The therapeutic efficacy of the combined anti-VCAM-1 ssDNA and anti-IL4Rα RNA aptamers in tumor-bearing mice was more pronounced compared with either anti-VCAM-1 ssDNA or anti-IL4Rα RNA aptamer, as assessed by monitoring tumor growth and inhibition using noninvasive BLI and MRI. The gene discussed is VCAM1; the disease is neoplasm.