However, we recently showed that the Hedgehog receptor Patched (Ptch1), which is overexpressed in many recurrent and metastatic cancers ([11,12], and Human Protein Atlas website http://www.proteinatlas.org/ENSG00000185920-PTCH1/cancer), is also expressed in ACC and contributes to resistance of ACC to treatment [13]. The gene discussed is PTCH1; the disease is metastatic malignant neoplasm.