Parathyroid hormone‐related peptide (PTHrP) and receptor activator of nuclear factor‐kappa‐B ligand (RANKL), which play significant roles in osteoclasts activation and bone metastases,17, 18 are found to be associated with NSCLC bone metastases.19, 20. The gene discussed is TNFSF11; the disease is non-small cell lung carcinoma.