In addition, given the close relationship between chronic inflammation and lung cancer and recent reports suggesting transcriptional features of injury responses in lung tumor cells, we also found that KRT8+CLDN4+ DATP-like cells can be observed within the tumor in patient tissue samples of lung adenocarcinoma (Figure S7I; Conway et al., 2016; Mantovani et al., 2008; Maynard et al., 2019; Moll et al., 2018). This evidence concerns the gene CLDN4 and lung cancer.