As a key protein in growth, AKT is an important apoptotic inhibitor in vivo, which induces the expression of various genes encoding anti‐apoptotic proteins,31 meanwhile, p‐AKT can directly regulate the formation of Bcl‐2/Bax heterodimer through PI3K‐Akt signaling pathway and inhibit tumor cell apoptosis.32 This evidence concerns the gene BAX and neoplasm.