Previous studies have proven that DTC can bind with copper ions to form an active anticancer DTC‐copper complex (CuET) in the body, and this complex binds firmly to NPL4 (an adaptor of p97 segregase) protein in the p97‐dependent ubiquitin proteasome pathway, inhibits the garbage protein degradation function and accumulates a large number of residual proteins in cancer cells, which eventually induces the apoptosis of cancer cells.12 Here, NPLOC4 is linked to cancer.