The most affected signalling pathways were the MAPK and the PTEN/PI3K/AKT/mTOR pathways, which are related to the most frequently altered genes found among the samples, and are in accordance with the genomic characteristics of the tumour types analysed (i.e., mainly breast, pancreas and colon cancers) [43, 44]. Here, AKT1 is linked to malignant colon neoplasm.