Phenotypic ex vivo analyses of immunodominant and subdominant influenza-specific A2/M158+CD8+ T cells involved CCR7 and CD45RA expression to characterize naïve (TN, CCR7+CD45RA+), central memory (TCM, CCR7+CD45RA-), effector memory (TEM, CCR7-CD45RA-) and effector (TEFF, CCR7-CD45RA+) T cells (Fig 2C). This evidence concerns the gene CCR7 and influenza.