Overall, the influenza-specific A2/M158+CD8+ TCRαβ repertoire revealed striking differences in TCRαβ clonal composition and diversity between subdominant (in HLA-B*27:05-expressing donors) and immunodominant (in non-HLA-B*27:05 individuals) A2/M158+CD8+ T cells, including reduced TRAV27 and TRBV19 “RS” motif usage, lower occurrence of the public TRBV19/TRAV27 clonotype, increased diversity and increased prevalence of private clonotypes. The gene discussed is CD8A; the disease is influenza.