In 104 HIV-1-infected patients, CD8+ T cell responses towards otherwise known immunodominant HIV-I-derived peptides presented on HLA-A1, -A2, -A3 and -A24, were reduced in the presence of HLA-B27 and HLA-B57 CD8+ T cell responses, indicating immunodomination of HLA-B27/B57 over other HLA types during HIV-1 infection [22]. This evidence concerns the gene CD8A and HIV-1 infection.