We determined if NLRP3-mediated inflammation is still activated beyond this time point in keloids by measuring protein levels of cleaved caspase-1 and IL-1β in keloids compared with burn skin (7–10 days after burn, average age 53 years and total body surface area [TBSA] 39%) and normal skin (Figure 1, A and B). This evidence concerns the gene NLRP3 and keloid.