Indeed, multiple PDEs, including isoforms of PDE3, PDE5, PDE6, PDE7, and PDE8, are highly and consistently expressed in a panel of AML and MM cell lines, including previously characterized statin‐sensitive (e.g., KMS11, OCI‐AML‐3) and insensitive (e.g., LP1) cell lines (Fig. 3A) [6, 23, 24]. The gene discussed is PDE5A; the disease is acute myeloid leukemia.