Given the emerging role of TG2 in neurite outgrowth and neural differentiation, either through its expression or its catalytic activities, coupled with its potential involvement in neurotoxicity, the aim of this study was to explore the modulation of TG2 activity by exposure to the OPs PSP and CPO in differentiating mouse N2a neuroblastoma cells. This evidence concerns the gene TGM2 and neuroblastoma.