Zhou L et al57 discover for the first time to our knowledge that, neddylation inactivation exhibits its anti‐tumor activity by suppressing the recruitment of monocytes/tumor‐associated macrophages in the tumor microenvironment, in response to Cullin‐1/NF‐κB‐modulated CCL2 derived from tumor cells.57 Here, CCL2 is linked to neoplasm.