SMARCA2 and Parkinson disease: Remarkably, when Brm was downregulated specifically in the DA neurons of PD model flies, the shortening of the median life span of both female and male Drosophila was prevented (Figure 3c–f, Table S4), while overactivation of Brm did not exhibit discernible effect (Figure 3c–f, Table S4), implicating that proper Brm levels might be crucial in healthy aging.