EBV proteins promote tumorigenesis through different mechanisms, one of which is by activating the human telomerase reverse transcriptase (hTERT) promoter by LMP1 through NF-κB, MAPK, and ERK1/2 signaling pathways in B cells and through c-MYC in NPC cells [111]. This evidence concerns the gene NFKB1 and nasopharyngeal carcinoma.