DNMT3A and macrophage activation syndrome: In addition, the same group performed a single-cell RNA sequencing analysis which revealed that the circulating monocytes of patients with aortic stenosis with CHIP driven by DNMT3A or TET2, or HF patients carrying DNMT3A mutations, have an increased expression of IL-1β IL-6 receptor, NLRP3 and CD163, a receptor involved in macrophage activation syndrome [43].