Among prominent risk factors in HF genesis, age and systemic inflammation play a prominent role, and the most commonly mutated CHIP-driver genes (TET2 and DNMT3A) are associated with poor prognosis [22,31,39,74] in HF [22,74], even with different effects on the hematopoiesis driven by the two mutated genes. This evidence concerns the gene DNMT3A and hydrops fetalis.