To study more in-depth the relationships between CVD and CHIP, in a later study, Jaiswal et al. carried out whole-exome sequencing on blood samples obtained from four case-control studies consisting of 4726 individuals with coronary heart disease and 3529 control individuals (matched on the basis of age, sex, type 2 diabetes status, smoking history in the prospective cohorts; for more details, see [14]). Here, STUB1 is linked to type 2 diabetes mellitus.