Coronavirus disease 2019 (COVID-19), also known as severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2), is an ongoing pandemic and a major healthcare concern.SARS-CoV-2 requires angiotensin-converting enzyme 2 (ACE2) protein to enter ACE2-expressing cells.1 ACE-2 is a component of renin-angiotensin system (RAS) activation which plays animportant role in hypertension. The gene discussed is ACE2; the disease is hypertensive disorder.