The findings that the interaction between KIF2C and TBC1D7 disturbs the formation of the TSC complex, resulting in the enhancement of mTORC1 signaling, led us to propose that KIF2C may antagonize the inhibitory function of TBC1D7 in mTORC1 signaling and HCC progression. The gene discussed is TBC1D7; the disease is hepatocellular carcinoma.