In accordance with this finding, treating HCC cells with Lithium chloride (LiCl), which acts as an agonist of the canonical Wnt signaling by inhibiting GSK-3β (Hedgepeth et al., 1997), was shown to enhance the KIF2C expression (Figs. S6C and 7B). This evidence concerns the gene GSK3B and hepatocellular carcinoma.