Taken together, our results indicate that upon transcriptional activation induced by Wnt/β-catenin signaling, KIF2C binds to TBC1D7, and the KIF2C/TBC1D7 interaction results in the dissociation of the TSC complex, thereby promoting mTORC1 signal transduction and HCC progression (Fig. 7I). This evidence concerns the gene TSC1 and hepatocellular carcinoma.