IDH2 and glioblastoma: In case of IDH-wildtype glioblastoma, patients aged ≥ 70 years should be treated with surgery and hypofractionated radiotherapy in case of an MGMT promoter-unmethylated tumour, while elderly patients with an MGMT promoter-methylated tumour should be treated by surgery and TMZ plus hypofractionated radiotherapy or surgery and TMZ alone (Weller et al. 2017b).