The use of fluorouracil (5-FU), another chemotherapy agent has shown promising results in mice tumours to decrease myeloid-derived suppressor cells (MDSC) and increase IFN-ƴ production by tumour specific CD8+ T cells infiltrating the tumour, promoting T cell-dependent anti-tumour responses in vivo (Vincent et al. 2010). This evidence concerns the gene CD8A and neoplasm.