In contrast, Neuzillet et al. report four subtypes to exist based on analysis of patient resected samples, each represented by differences in molecular and functional features which include ECM, immune signatures, intra-tumoural spatial pattern of expression of vimentin, αSMA and proliferation rate, tumour promoting and chemoprotective capabilities and distinct prognostic impact (Elyada et al. 2019) (Figs. 2 and 3). The gene discussed is ACTA1; the disease is neoplasm.