Several interactomic studies using either co-immunoprecipitation or pull-down assays in conjunction with quantitative proteomic analyses have revealed hnRNP U to be a binding partner of both wild-type and ALS-mutant forms of TDP-43, FUS and Ataxin 2 [16, 56, 116]. Here, TARDBP is linked to amyotrophic lateral sclerosis.