One study of ECFCs isolated from diabetic placental tissue found that increased levels of PLAC8 (Placenta-Associated 8), linked with impaired proliferation and increased senescence, were correlated with reduced DNA methylation at 17 CpG sites, alterations which were reversed following RNAi depletion of PLAC8 [64], highlighting a possible role for this protein and associated DNA methylation changes in hyperglycaemia-induced ECFC dysfunction. Here, PLAC8 is linked to Hyperglycemia.