CCN2 and hydrops fetalis: The majority of such in vivo studies have primarily focussed on DNA methylation changes in cardiomyocytes [10, 52, 53], with one group suggesting that regulation of disease-associated genes (e.g. CTGF, NPPA and NPPB) in cardiomyocytes sorted from end-stage HF patients may rather occur primarily through alteration of histone signatures [52].