In C-MPNSTs, MethylCIBERSORT detected a predominance of endothelial cells (p = 0.023, Kruskal–Wallis test), neutrophils (p = 0.031, Kruskal–Wallis test), and cancer-associated fibroblasts in the TME (p = 0.028, Kruskal–Wallis test), while a strong enrichment for CD8+ T cells (p = 0.0032, Kruskal–Wallis test) and CD14+ cells (p = 0.006, Kruskal–Wallis test) was seen in the SCM group set (Fig. 5c). The gene discussed is CD8A; the disease is cancer.