Based on liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), Cheow et al.111 identified 252 upregulated EV proteins after MI and created a potential panel for the early diagnosis of MI, including apolipoprotein C-III, apolipoprotein D, platelet glycoprotein Ib alpha chain, complement C1q subcomponent subunit A, and complement C5. The gene discussed is C5; the disease is myocardial infarction.