In the univariate analysis, male gender, older age, cirrhosis, lower platelet counts (< 150 × 109/l), lower albumin levels, higher bilirubin levels, the ALBI27 score (which is consisted albumin and bilirubin and useful for the evaluation of liver function), alcohol drinking, and detectable HBV DNA were significant predictive factors of HCC. The gene discussed is ALB; the disease is Cirrhosis.