A recent study showed that suppressing EZH2 activity with GSK343 ameliorated experimental intestinal inflammation and delayed the onset of colitis-associated cancer accompanied by a gradual loss of H3K27me3 expression.204 DZNep (3-deazaneplanocin A), a potent chemical inhibitor of S-adenosylhomocysteine hydrolase that modulates chromatin accessibility through inhibition of histone methyltransferases, including EZH2,205 can lead to a significant reduction in H3K27me3 with a marked reduction in cell proliferation and migration in CRC. The gene discussed is EZH2; the disease is colorectal carcinoma.