PPARA and hepatocellular carcinoma: During the development of colon cancer, intestine-specific peroxisome proliferator-activated receptor alpha (PPARa) deficiency promotes PRMT6 expression via the RB1/E2F pathway and increases the enrichment of H3R2 asymmetric dimethylation (H3R2me2a) in the promoter of p27.70 Another study demonstrated that PRMT9 promotes HCC invasion and metastasis by activating PI3K/Akt/GSK‐3β/Snail signaling.71 However, the study did not explain whether this activation was caused by histone methylation of related genes, and this possibility needs further investigation.