CD274 and pachyonychia congenita: Verticillin A is less toxic but exhibits greater efficacy than decitabine and vorinostat.127 Lu et al. proved that a sublethal dose of verticillin A effectively overcomes the resistance of human PC cells to gemcitabine and suppresses tumor growth.122 Furthermore, verticillin A was recently found to have a synergistic effect with anti-PD-L1 therapy in PC.135