For instance, Yi et al. reported that HIF1a stabilization under hypoxic conditions leads to KDM1A upregulation at the mRNA and protein levels in PC,147 while progression of PC induces a hypoxic microenvironment through the Warburg effect and results in the production of a large amount of HIF1.148,149 A recent study conducted by Jiang et al. in CRC also supported this conclusion. Here, SETD2 is linked to pachyonychia congenita.