O-linked N-acetylglucosamine transferase (OGT), which is negatively regulated by miR-101, enhances EZH2 protein stability and function and promotes the enrichment of repressive H3K27me3 marks on the miR-101 promoter region, resulting in the upregulation of OGT.150 This process creates a vicious cycle and further exacerbates tumor progression. This evidence concerns the gene EZH2 and neoplasm.