Each of these modifications is associated with gene activity, gene silencing, or insulation between active and inactive gene regions.2 For example, the transcription factor FOXA1 drives large-scale enhancer reprogramming through H3K27ac (acetylation of lysine 27 of histone 3) modulation, thereby promoting PC progression.3 An increase in H3K9me2 in the promoter region of RARRES3 gene represses its transcription, thereby contributing to cancer cell migration in hepatocellular carcinoma (HCC).4 This evidence concerns the gene PLAAT4 and hepatocellular carcinoma.