PRMT5 and neoplasm: For example, recent studies have demonstrated that upregulated PRMT5 can epigenetically silence the expression of the E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (FBW7) by increasing H4R3me2s and H3K9me3 and decreasing H3K9ac in PC,72 indicating that PRMT5 can recruit histone KMTs and histone deacetylases to promote tumor development.