For example, recent studies have demonstrated that upregulated PRMT5 can epigenetically silence the expression of the E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (FBW7) by increasing H4R3me2s and H3K9me3 and decreasing H3K9ac in PC,72 indicating that PRMT5 can recruit histone KMTs and histone deacetylases to promote tumor development. This evidence concerns the gene FBXW7 and neoplasm.