For example, decreases in H3K27me3 in the MMP7 and HMGA2 promoter regions promote the progression of PC in Brg1-depleted PC cells,168 as MMP7 facilitates tumor cell invasion and HMGA2 promotes invasion and migration through EMT.169,170 Moreover, two other MMP family proteins, MMP9 and MMP14, are also activated during the development of digestive cancers. Here, HMGA2 is linked to pachyonychia congenita.