The carriers of the PRKN C-G-C-A-T-T-C and PACRG A-T-A-T (adjusted OR = 1.191, 95% CI = 1.015–1.660, P < 0.001), PACRG A-T-A-T and BMI > 24 kg/m2 (adjusted OR = 1.327, 95% CI = 0.612–2.285, P < 0.001), and PRKN–PACRG C-G-T-G-T-T-C-A-T-C-T and BMI > 24 kg/m2 (adjusted OR = 1.066, 95% CI = 0.532–1.863, P < 0.001) increased the risk of hyperlipidaemia. The gene discussed is PACRG; the disease is hyperlipidemia.