PDCD4 and cancer: The tumor suppressor programmed cell death 4 (PDCD4) protein was first described in cancer studies and has been shown to regulate protein synthesis by inhibition of EIF4A helicase activity (Yang et al. 2003; Suzuki et al. 2008; Matsuhashi et al. 2019) and via interaction with specific RNA motives present in a particular subset of target mRNAs (Loh et al. 2009; Wedeken et al. 2011; Biyanee et al. 2015).