Although misregulation of PDCD4 in a variety of tumors (Zhang et al. 2006; Gao et al. 2007; Mudduluru et al. 2007; Zhen et al. 2016) suggests an important role in cancer development (Zhang et al. 2006; Gao et al. 2007; Mudduluru et al. 2007; Zhen et al. 2016), the full scope of PDCD4 translational targets and its potential role in other growth-dependent cellular systems has only recently started to be elucidated (Haas et al. 2020). This evidence concerns the gene PDCD4 and cancer.