Importantly, we confirmed that in both cortical and DRG neurons the addition of PDCD4 siRNA led to a significant decrease in PDCD4 levels detected by immunochemistry (Supplemental Fig. S1B,C), an effect further confirmed by immunoblotting using the neuroblastoma N2a cell line, which has high transfection efficiency (Supplemental Fig. S1D). Here, PDCD4 is linked to neuroblastoma.