In a model with both Trp53 deletion and mutant KrasG12D, LUAD originated from both Ad5-CC10-Cre or Ad5-SPC-Cre injected mice; in this setting, the tumor development was accelerated, and mice developed metastasis (Sutherland et al. 2014), indicating that different cells can function as the cell of origin of LUAD with carcinomas originating from club cells exhibiting more pronounced papillary features. This evidence concerns the gene SFTPC and neoplasm.