Similarly, loss of CREBBP (Trp53F/F;Rb1F/F;CrebbpF/F mice) (Jia et al. 2018) or overexpression of L-MYC (Trp53F/F;Rb1F/F; invCAG-Mycl-Luc mice) (Semenova et al. 2016) also give rise to SCLC upon infection with Ad5-CGRP-Cre as does deletion of Rb1, Trp53, and Pten (Cui et al. 2014; McFadden et al. 2014). This evidence concerns the gene RB1 and small cell lung carcinoma.