We observed a significant increase in cleaved caspase-3 fluorescence intensity in AD model flies (elav-Gal4C155/+;+/+;UAS-Aβ42E693G/+ and elav-Gal4C155/+;+/+;UAS-APP.C99-UAS-MAPT/+) (Fig. 8C′,c′,E′,e′,G′) as compared to elav-Gal4C155/+;+/+;+/+ flies (Fig. 8A′,a′,G′). This evidence concerns the gene CASP3 and Alzheimer disease.