It was discovered that the rough eye phenotype as well as ommatidial and bristles arrangements associated with AD model flies were significantly improved by Miro overexpression [GMR-GAL4-UAS-TauWT/UAS-Miro, GMR-GAL4-UAS-Aβ42(Human)/UAS-Miro and GMR-GAL4/UAS-Miro;UAS-ApplRNAi/+] (Fig. 2B–D,B′–D′). This evidence concerns the gene LGALS4 and Alzheimer disease.