While overexpression of Miro in AD model flies (elav-Gal4C155/+;UAS-Miro/+;UAS-Aβ42E693G/+ and elav-Gal4C155/+;UAS-Miro/+;UAS-APP.C99-UAS-MAPT/+) significantly decreased the relative CAT gene expression level to 2.1- and twofold, respectively, as compared to the respective AD model flies (Fig. 5c). This evidence concerns the gene APP and Alzheimer disease.