We observed that relative expression of the Miro gene was significantly increased in AD model flies [GMR-GAL4-UAS-TauWT/+, GMR-GAL4-UAS-Aβ42(Human)/+ and GMR-GAL4/+;UAS-ApplRNAi/+] to 1.7-, 2.2- and twofold, respectively, as compared to GMR-GAL4/+ flies (Fig. 4K). This evidence concerns the gene LGALS4 and Alzheimer disease.