This decreased ATP in AD model flies was significantly increased to 4.3×105 and 4.5×105 μM μg−1 of protein in Miro overexpressing AD model flies such as elav-Gal4C155/+;UAS-Miro/+;UAS-Aβ42E693G/+ and elav-Gal4C155/+;UAS-Miro/+;UAS-APP.C99-UAS-MAPT/+, respectively (Fig. 7A). The gene discussed is MAPT; the disease is Alzheimer disease.