APPL1 and Alzheimer disease: Thus, to find out the participation of Miro in AD, we have performed a genetic interaction study between the mitochondrial axonal transport gene Miro and the AD-associated genes (Tau, Aβ42 and Appl) in Drosophila. The genetic interaction study was performed by crossing the AD model flies with Miro overexpressing/knockdown strains and examining the offspring for any phenotypic manifestation.