Overexpression of Miro in AD model flies such as elav-Gal4C155/+;UAS-Miro/+;UAS-Aβ42E693G/+ (Fig. 5M–P,a) and elav-Gal4C155/+;UAS-Miro/+;UAS-APP.C99-UAS-MAPT/+ (Fig. 5U–X,a) showed a significant reduction of MitoSOX Red fluorescence suggesting that Miro overexpression helps in the reduction of mitochondrial ROS level in AD model flies. The gene discussed is MAPT; the disease is Alzheimer disease.