The increased number of vacuoles in AD model flies was significantly decreased to 7.8 and 11.6 by Miro overexpression such as elav-Gal4C155/+;UAS-Miro/+;UAS-Aβ42E693G/+ (Fig. 8D′′,d′′,G′′) and elav-Gal4C155/+;UAS-Miro/+;UAS-APP.C99-UAS-MAPT/+, respectively (Fig. 8F′′,f′′,G′′). This evidence concerns the gene APP and Alzheimer disease.