MAPT and Alzheimer disease: The decreased relative expression of the ATP synthase gene was increased to 2.2- and 1.8-fold in Miro overexpressing AD model flies such as elav-Gal4C155/+;UAS-Miro/+;UAS-Aβ42E693G/+ and elav-Gal4C155/+;UAS-Miro/+;UAS-APP.C99-UAS-MAPT/+, respectively (Fig. 7B).