The knockdown of Miro in the AD model flies genetic background (GMR-GAL4-UAS-TauWT/+;UAS-MiroRNAi/+) significantly decreased the fly eye width to 182.12 μm as compared to the AD model flies having an eye width of 69.59 μm (Fig. 2I). This evidence concerns the gene LGALS4 and Alzheimer disease.