Further, we observed that the median lifespans of Miro overexpressing AD model flies (elav-Gal4C155/+;UAS-Miro/+;UAS-Aβ42E693G/+ and elav-Gal4C155/+;UAS-Miro/+;UAS-APP.C99-UAS-MAPT/+) were significantly extended to 48 days and 44 days, respectively, as compared to AD model flies (elav-Gal4C155/+;UAS-Miro/+;UAS-Aβ42E693G/+ and elav-Gal4C155/+;UAS-Miro/+;UAS-APP.C99-UAS-MAPT/+), which had median lifespans of 32 days and 34 days, respectively (Fig. 3). Here, APP is linked to Alzheimer disease.