MAPT and Alzheimer disease: While overexpression of Miro in AD model flies (elav-Gal4C155/+;UAS-Miro/+;UAS-Aβ42E693G/+ and elav-Gal4C155/+;UAS-Miro/+;UAS-APP.C99-UAS-MAPT/+) significantly decreased the DCF fluorescence in adult brain as compared to the control (Fig. 5b).