APP and Alzheimer disease: This higher level of Mn-SOD gene expression was significantly decreased to 0.8- and 0.6-fold in Miro overexpressing AD model flies such as elav-Gal4C155/+;UAS-Miro/+;UAS-Aβ42E693G/+ and elav-Gal4C155/+;UAS-Miro/+;UAS-APP.C99-UAS-MAPT/+, respectively (Fig. 5c).