Increased burden of deleterious variants in GCH1 gene was detected in PD patients of the WES cohort, but not in the late-onset patients of the WGS cohort, which was in line with previous studies on late-onset PD [13], suggesting that the pathophysiology of PD with early-onset or familial history may differ from that of the late-onset PD. Here, GCH1 is linked to Parkinson disease.