Apart from the earlier reported variants, we also found several novel missense or loss-of-function variants of GCH1 in our PD cohort, including p.I193M (n = 2), p.F122Ifs*1, p.M102L, p.Q87Sfs*29, p.P86S, p.P39L, and p.E11A (n = 1 each), of which p.I193M, p.F122Ifs*1, p.Q87Sfs*29, and p.P86S were predicted to be deleterious in our in silico analysis (Table S5). This evidence concerns the gene GCH1 and Parkinson disease.