In the present study, we first analyzed the burden of GCH1 variants in coding regions in PD patients using whole-exome sequencing (WES), and then examined rare and common variants in the reported regulatory elements of GCH1 including promoter, enhancer, untranslated regions (UTRs)/introns and eQTLs, using whole-genome sequencing (WGS). The gene discussed is GCH1; the disease is Parkinson disease.